Galacto Oligosaccharides Analysis Essay

Galacto-oligosaccharides (GOS) have been added to infant formulas and conventional foods as prebiotics all over the world. The present study was conducted to assess the subchronic toxicity of a GOS syrup (VITAGOS™) when administered orally by gavage daily at 0, 1020, 2041, and 4082 mg GOS syrup/kg/day to male and female Sprague-Dawley rats to deliver doses of 0, 500, 1000, and 2000 mg GOS/kg/day for 90 days. Throughout the entire treatment period, no abnormal clinical signs or mortalities were observed. Similarly, no test article-related toxicologically adverse findings were seen in body weight, feed consumption, ophthalmological findings, hematology, coagulation, clinical chemistry, urinalysis, organ weights, and gross pathology or histopathology. Significant increases in the cecum weight of males and females treated with 2000 mg GOS/kg/day were associated with mucosal hypertrophy/hyperplasia; no changes in the cecum were noted at lower doses. The organ weight and histopathological changes noted in the cecum are consistent with findings in rats administered other poorly digestible and fermentable substances; thus, this is considered to be an adaptive rather than toxic response. The No-Observed-Adverse-Effect-Levels for VITAGOS™ is 4082 mg GOS syrup/kg body weight/day or 2000 mg GOS/kg body weight/day.

Citation data is made available by participants in Crossref's Cited-by Linking service. For a more comprehensive list of citations to this article, users are encouraged to perform a search inSciFinder.

  • Biochemical Characterization of the Functional Roles of Residues in the Active Site of the β-Galactosidase from Bacillus circulans ATCC 31382

    HuifangYinTjaardPijningXiangfengMengLubbertDijkhuizenSander S.van Leeuwen

    Biochemistry201756 (24), 3109-3118

    Abstract | Full Text HTML | PDF | PDF w/ Links

  • Prebiotic Galactooligosaccharide Metabolism by Probiotic Lactobacilli and Bifidobacteria

    TaksawanThongaramJennifer L.HoeflingerJoMayChowMichael J.Miller

    Journal of Agricultural and Food Chemistry201765 (20), 4184-4192

    Abstract | Full Text HTML | PDF | PDF w/ Links

  • Structural Elucidation of Enzymatically Synthesized Galacto-oligosaccharides Using Ion-Mobility Spectrometry–Tandem Mass Spectrometry


    Journal of Agricultural and Food Chemistry201664 (18), 3609-3615

    Abstract | Full Text HTML | PDF | PDF w/ Links

  • In Vitro Fermentation of Porcine Milk Oligosaccharides and Galacto-oligosaccharides Using Piglet Fecal Inoculum

    ElisabettaDifilippoFeipengPanMadelonLogtenbergRianne (H.A.M.)WillemsSaskiaBraberJohannaFink-GremmelsHenk A.ScholsHarryGruppen

    Journal of Agricultural and Food Chemistry201664 (10), 2127-2133

    Abstract | Full Text HTML | PDF | PDF w/ Links

  • Oligosaccharides in Urine, Blood, and Feces of Piglets Fed Milk Replacer Containing Galacto-oligosaccharides

    ElisabettaDifilippoMoniqueBettonvilRianne (H.A.M.)WillemsSaskiaBraberJohannaFink-GremmelsPrescilla V.JeurinkMargriet H. C.SchotermanHarryGruppenHenk A.Schols

    Journal of Agricultural and Food Chemistry201563 (50), 10862-10872

    Abstract | Full Text HTML | PDF | PDF w/ Links

  • Enzymatic Decoration of Prebiotic Galacto-oligosaccharides (Vivinal GOS) with Sialic Acid Using Trypanosoma cruzitrans-Sialidase and Two Bovine Sialoglycoconjugates as Donor Substrates

    Maarten H.WilbrinkGeert A.ten KatePeterSandersGerrit J.GerwigSander S.van LeeuwenErikSallomonsBertKlarenbeekJohannes A.HageCarine A.van VuureLubbertDijkhuizenJohannis P.Kamerling

    Journal of Agricultural and Food Chemistry201563 (25), 5976-5984

    Abstract | Full Text HTML | PDF | PDF w/ Links

  • Isomer-Specific Consumption of Galactooligosaccharides by Bifidobacterial Species

    Kyle S.PeacockL. ReneeRuhaakMan KiTsuiDavid A.Mills

  • 0 thoughts on “Galacto Oligosaccharides Analysis Essay”


    Leave a Comment

    Your email address will not be published. Required fields are marked *